pentobarbital will lower the level or result of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with solid CYP3A4 inducers may end up in diminished serum concentrations and lack of antimalarial efficacypentobarbital and olopatadine intranasal both of those enha